P291 Screening for Coeliac Disease in adults with cystic fibrosis in Wales

Emerging evidence suggests an increased prevalence of Coeliac Disease (CD) in People with Cystic Fibrosis (PwCF) when compared to the UK population. The objective was screen patients All Wales Adult Centre (AWACFC) for CD and compare results within adult general population, which is estimated be 1 100. serology tests (IgA anti-tissue Transglutaminase (tTG) antibodies) were added patient annual review blood testing from 2019 2021. An AWACFC Screening Management Flowchart created, based on , used interpret provide intervention guidance. 262 PwCF, 109 (42%) female, screened at review, one already known have CD. 215 (82%) had pancreatic insufficiency (PI). Of 261 without prior disease, two new identified. These reported symptoms gastrointestinal disturbance a skin rash (subsequently diagnosed as dermatitis herpetiformis), respectively. indicate our cohort 87, higher than three male symptom relief implementation gluten-free diet. screened, 16 low IgA therefore Anti-IgG tTG testing. support emerging that PwCF may Additionally, masked by PI, further supporting recommendation routine screening. Our experience shows ease feasibility adding this serological test